#262: Fasting Series — All about intermittent fasting with renowned researcher Dr. Mark Mattson
"We've proposed and published that a major driving force for brain evolution, including human brain evolution, was food scarcity." –Dr. Mark Mattson
In this episode in the fasting series on Veggie Doctor Radio, we learn from Dr. Mark Mattson about his decades of research on intermittent fasting and its effects on health, including cognitive function.
Dr. Yami’s Episode Takeaways:
Intermittent fasting is not a diet; it is an eating pattern.
It takes at least 12 hours of fasting to trigger the metabolic switch that occurs after you deplete glycogen stores.
Exercising during a fasted state enhances the use of fat and ketones which is why we see an additive positive effect of exercise during fasting.
Fasting provides benefits independent of calorie restriction
The human body evolved to function in a food-deprived state
It takes 2-4 weeks to adapt to a new eating pattern, so be patient when you adopt TRE
Fasting has positive cognitive effects and may decrease the risk of Alzheimer’s disease
Fasting alone can lead to positive metabolic effects, including improved insulin sensitivity and cardiovascular benefits independent of weight loss
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Dr. Mark Mattson
More about my honored guest:
Mark Mattson is the former Chief of the Laboratory of Neurosciences at the National Institute on Aging, and is now on the faculty of Neuroscience at Johns Hopkins University School of Medicine. His research has advanced an understanding of the cellular signaling mechanisms that control the formation and plasticity of neuronal networks in the brain, and cellular and molecular mechanisms of brain aging and neurodegenerative disorders. His research has also elucidated how the brain responds adaptively to challenges such as fasting and exercise, and he has used that information to develop novel interventions to promote optimal brain function throughout life. Dr. Mattson is among the most highly cited neuroscientists in the world with more than 900 publications and 200,000 citations. He was elected a Fellow of the American Association for the Advancement of Science and has received many awards including the Metropolitan Life Foundation Medical Research Award and the Alzheimer’s Association Zenith Award.
Mattson is the author of the book The Intermittent Fasting Revolution: The Science of Optimizing Health and Enhancing Performance. Johns Hopkins – Dr. Mark Mattson
The following podcast series is intended to provide education about the potential health and longevity benefits of different forms of fasting including time restricted eating, intermittent fasting and extended water only fasting. Please be aware that in this series we will be discussing different forms of fasting and food restriction and in some cases references to body size and weight may be mentioned. This material and these methods are not appropriate for children, pregnant people or people with certain medical conditions. Please do not attempt these practices without medical supervision as it could be very dangerous. These concepts may also be triggering for people with disordered eating and eating disorders so please practice discretion before listening to these episodes. The information on this blog, website and podcast is for informational purposes only. It is not meant to replace careful evaluation and treatment. If you have concerns about your or your child’s eating, nutrition or growth, consult a doctor.
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The Intermittent Fasting Revolution: The Science of Optimizing Health and Enhancing Performance by Dr. Mark Mattson
Sculptor and Destroyer: Tales of Glutamatethe Brain's Most Important Neurotransmitter by Dr. Mark Mattson
Dr. Mark Mattson’s citations: https://scholar.google.com/citations?user=N3ObarMAAAAJ&hl=en&oi=ao
Ongoing and recently completed clinical trials: https://clinicaltrials.gov/ “Search Intermittent Fasting”
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